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Peptide Insights provides information about peptides based on published scientific research and clinical literature. This content is designed to help you understand the science, not to guide personal medical decisions.
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Vasoactive Intestinal Peptide · VIP 28 · VIP neuropeptide
Potent anti-inflammatory neuropeptide studied for POTS, MCAS, and immune modulation
Typical Dose
100 mcg once daily
Route
Subcutaneous
Frequency
Once or twice daily
Cycle
4-12 weeks
Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide found throughout the nervous system, GI tract, and immune system. Research has explored VIP for its potent anti-inflammatory and immunomodulatory properties, its role in circadian rhythm regulation, neuroprotection, and its potential in treating conditions such as POTS, MCAS, and chronic inflammatory conditions.
VIP binds to VPAC1 and VPAC2 receptors, increasing intracellular cAMP. This leads to smooth muscle relaxation (vasodilation), inhibition of pro-inflammatory cytokines (TNF-alpha, IL-6, IL-12), promotion of anti-inflammatory cytokines (IL-10), and modulation of T-cell and dendritic cell function.
Typical Dose
100 mcg once daily
Dose Range
50-200 mcg/day
Frequency
Once or twice daily
Route
Subcutaneous injection or intranasal
Cycle Length
4-12 weeks
CLINICAL NOTES
Intranasal delivery is preferred for CNS applications. Monitor blood pressure due to vasodilatory effects.
IMPORTANT DISCLAIMER
This information is for educational purposes only. Always consult a qualified healthcare provider before starting any peptide protocol. Individual responses vary and medical supervision is recommended.
VIP (Vasoactive Intestinal Peptide) is used for inflammation, gut health, and immune modulation.
BPC-157 + VIP is a powerful gut healing combination targeting different aspects of GI inflammation.
TA-1's immune modulation complements VIP's anti-inflammatory effects.
LL-37 + VIP covers both antimicrobial and anti-inflammatory aspects of gut health.
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