💪 Muscle Growth & PerformancePreclinical

CJC-1295 / Ipamorelin

CJC-1295 with DAC / Ipamorelin combo · GH Stack · GHRH/GHRP combo

The gold-standard GH secretagogue stack for physiological growth hormone release

Typical Dose

CJC-1295: 200 mcg + Ipamorelin: 200 mcg daily

Route

Subcutaneous

Frequency

Once or twice daily

Cycle

8-16 weeks

Overview

CJC-1295/Ipamorelin is one of the most popular peptide combinations in growth hormone research. CJC-1295 is a GHRH analog that stimulates the pituitary to produce GH, while Ipamorelin is a selective ghrelin receptor agonist that amplifies GH pulses without significantly raising cortisol or prolactin. Together, they produce a strong, physiological GH pulse that mimics the natural pulsatile release pattern.

Key Benefits

Increased growth hormone secretion
Enhanced muscle protein synthesis
Reduced body fat (especially visceral)
Improved sleep quality and recovery
Enhanced bone density
Anti-aging effects via IGF-1 upregulation
Minimal cortisol or prolactin elevation

Mechanism of Action

CJC-1295 binds to GHRH receptors on pituitary somatotrophs, stimulating GH synthesis and release. Its drug affinity complex (DAC) extends its half-life to 6-8 days. Ipamorelin binds to the ghrelin receptor (GHS-R1a), amplifying the GH pulse. The combination produces synergistic GH release while maintaining the natural pulsatile pattern.

Dosing Protocol

Typical Dose

CJC-1295: 200 mcg + Ipamorelin: 200 mcg daily

Dose Range

100-300 mcg each per injection

Frequency

Once or twice daily

Route

Subcutaneous injection

Cycle Length

8-16 weeks

CLINICAL NOTES

Inject 30-60 minutes before sleep to align with natural GH pulse. Fast for 2 hours before injection. Cycle 5 days on, 2 days off.

Reconstitution calculator and cycle planner pre-filled with CJC-1295 / Ipamorelin defaults

Side Effects & Safety

Water retention (transient)
Tingling or numbness (extremities)
Headache
Flushing
Increased hunger

IMPORTANT DISCLAIMER

This information is for educational purposes only. Always consult a qualified healthcare provider before starting any peptide protocol. Individual responses vary and medical supervision is recommended.

Research References

Common Stacks

This pre-made combination is already a complete GH stack. Adding recovery peptides is the most common complement.

Frequently Asked Questions

Quick Reference

CategoryMuscle Growth & Performance
Research StatusPreclinical
Typical DoseCJC-1295: 200 mcg + Ipamorelin: 200 mcg daily
RouteSubcutaneous
Cycle8-16 weeks

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