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Peptide Insights provides information about peptides based on published scientific research and clinical literature. This content is designed to help you understand the science, not to guide personal medical decisions.
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Human Growth Hormone · Somatropin · rhGH · Growth Hormone
Recombinant human growth hormone studied for body composition, recovery, and anti-aging
Typical Dose
2-4 IU once daily
Route
Subcutaneous
Frequency
Once daily (morning or before bed)
Cycle
12-24 weeks
Recombinant Human Growth Hormone (rhGH, somatropin) is a synthetic version of the 191-amino acid peptide hormone naturally produced by the anterior pituitary gland. GH plays a central role in growth, body composition, cell repair, and metabolism. It stimulates the liver to produce IGF-1 (Insulin-like Growth Factor 1), which mediates many of its anabolic effects.
HGH binds to GH receptors on target cells and activates the JAK2-STAT5 signaling pathway. In the liver, this stimulates IGF-1 production, which promotes protein synthesis, cell proliferation, and anabolic metabolism. HGH directly stimulates lipolysis in adipose tissue and promotes glucose uptake in muscle.
Typical Dose
2-4 IU once daily
Dose Range
1-6 IU/day
Frequency
Once daily (morning or before bed)
Route
Subcutaneous injection
Cycle Length
12-24 weeks
CLINICAL NOTES
Start at 1 IU daily. Inject in the morning or before bed. Rotate injection sites. Monitor IGF-1 levels and watch for side effects at higher doses.
IMPORTANT DISCLAIMER
This information is for educational purposes only. Always consult a qualified healthcare provider before starting any peptide protocol. Individual responses vary and medical supervision is recommended.
HGH is typically run with insulin sensitizers and recovery peptides to maximize benefits and manage side effects.
Ipamorelin's natural GH pulse complements exogenous HGH for a more physiological GH profile.
BPC-157 supports joint and connective tissue health under HGH's anabolic load.
NAD+ supports the metabolic demands of HGH therapy.
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